AIP | DIP | UIP | |
Prodrome | Abrupt (1 to 2 weeks) | Subacute (weeks to months) | Chronic (>12 months) |
Chest radiography | Diffuse, bilateral air-space opacification | Ground-glass opacity in lower lung zones |
Bilateral reticular opacities Honeycombing Lower zone predominance |
HRCT features |
Bilateral, symmetric areas of ground-glass opacity Bilateral air space consolidation |
Diffuse ground-glass opacity in middle and lower lungzones |
Intralobular interstitial opacities Irregular interlobular septal thickening Traction bronchiectasis and honeycombing Lower zone predominance |
Histopathologic features | Diffuse, uniform organizing diffuse alveolar damage (hyaline membranes) | Diffuse, uniform intraalveolar macrophage accumulation | Variegated, patchy, subpleural interstitial fibrosisand honeycombing |
Treatment |
Mechanical ventilation Glucocorticoid responsiveness unknown |
Glucocorticoid responsive | Poor response to glucocorticoids or cytotoxic agents |
Prognosis | 60 percent mortality in <6 months | 5 percent mortality in 5 years | 50 to 70 percent mortality in 5 years |
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