Genotype C | Genotype B | |
Prevalence of HBeAg | High | Low |
Spontaneous HBeAg seroconversion | Late | Early |
Histological activity | High | Low |
Rate of progression to cirrhosis | High | Low |
Risk of HCC | High | Low (Japan, China) |
Variable (Taiwan) | ||
Frequency of PC variant (G1896A) | Low | High |
Frequency of CP variant (A1762T, G1764A) | High | Low |
Response to IFN | Low | High |
(Similar in 1 study on PEG-IFN) | ||
Response to nucleotide(side) analogues | ||
On treatment | Similar | Similar |
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