Version May 2024
| NSAIDs that preferentially inhibit COX-1 and cross-react with aspirin |
| Diclofenac |
| Etodolac |
| Fenoprofen |
| Floctafenine (available outside of the United States) |
| Flurbiprofen |
| Ibuprofen |
| Indomethacin |
| Ketoprofen |
| Ketorolac |
| Meclofenamate |
| Mefenamic acid |
| Naproxen |
| Oxaprozin |
| Piroxicam |
| Sulindac |
| Tiaprofenic acid (available outside of the United States) |
| Nonopioid analgesics and nonacetylated salicylates that are poor inhibitors of COX-1 and only with higher concentrations of drug; cross-reactions with higher doses |
| Acetaminophen (paracetamol) |
| Diflunisal |
| Salsalate |
| Bismuth subsalicylate, bismuth salicylate (NOTE: Absorption of salicylate occurs from oral bismuth salicylates [eg, as used for treatment of diarrhea and other gastrointestinal complaints]) |
| NSAIDs that preferentially inhibit COX-2 but also inhibit COX-1 when higher doses given; cross-reactions with higher doses |
| Meloxicam |
| Nabumetone |
| Nimesulide (available outside of the United States) |
| Highly selective COX-2 inhibitors that do not inhibit COX-1; cross-reactions are rare (may occur at the highest doses) |
| Celecoxib |
| Etoricoxib (available outside of the United States) |
| Parecoxib (parenteral; available outside of the United States) |
| Lumiracoxib (limited availability outside of the United States) |
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