Causes of hemolysis that may be present in a patient receiving a transfusion

Immune-mediated

Acute hemolytic transfusion reaction (AHTR)

Delayed hemolytic transfusion reaction (DHTR)

Non-immune-mediated

Thermal injury

Heat

Cold

Osmotic injury

Mechanical injury

Infection

Congenital hemolytic anemia

Acquired hemolytic anemia

Drug-induced hemolytic anemia

Refer to UpToDate for discussion of hemolytic transfusion reactions. Some of these conditions may occur in a patient receiving a transfusion but are not caused by the transfusion.

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Causes of hemolysis that may be present in a patient receiving a transfusion