Single-agent cytotoxic chemotherapy for desmoid tumors

Agent	Number of patients studied	Dose	Response	Duration of response	Author; year
Doxorubicin	1	70 mg/m² every three weeks Dose reduced after two cycles to 50 mg/m² Cumulative dose of 450 mg/m²	PR	>4 years after cessation of chemotherapy	Seiter K; 1993
Doxorubicin	6	NR	3 PR	NR	de Camargo VP; 2010
Epirubicin	1	30 mg/m² every three weeks	PR	>1 year	Giaccone G; 1989
Pegylated liposomal doxorubicin	1 adult 3 children	20 to 50 mg/m² Cumulative dose of 160 to 430 mg/m²	3 PR 1 SD	9 to 40 months of follow-up, no progression seen	Wehl G; 2004
Pegylated liposomal doxorubicin	22	NR	8 PR	NR	de Camargo VP; 2010
Pegylated liposomal doxorubicin	14	40 to 50 mg/m² every four weeks, up to six cycles	4 PR 10 SD	9 to 45 months	Constantinidou A; 2010

PR: partial response, ≥30% reduction in maximal dimension; NR: not reported; SD: stable disease.

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