Phenytoin toxicity: Approximate correlation of serum concentration and clinical signs

Serum concentration	Clinical findings
<10 mg/L (40 µmol/L)	None
10-20 mg/L (40-80 µmol/L) (therapeutic)	Mild nystagmus
20-30 mg/L (80-120 µmol/L)	Nystagmus
30-40 mg/L (120-160 µmol/L)	Ataxia, slurred speech, nausea, vomiting
40-50 mg/L (160-200 µmol/L)	Lethargy and confusion
>50 mg/L (>200 µmol/L)	Coma

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