Disseminated neonatal HSV

Adrenals (A) and liver (B) of a neonate who died from disseminated neonatal herpes simplex virus (HSV) disease, showing hemorrhagic lesions on the adrenals and patchy white areas on the liver capsule. Microscopic histopathologic sections of the involved organs (C and D) showed coagulative necrosis, hemorrhage, and Cowley type A and B viral inclusion bodies, characteristic of HSV infection. Viral culture of the organs grew HSV type 2.