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تعداد آیتم قابل مشاهده باقیمانده : 3 مورد
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Major causes of thrombocytopenia in children

Major causes of thrombocytopenia in children
Destructive thrombocytopenias Decreased platelet production
Immune-mediated
  • Immune thrombocytopenia (ITP)
  • Drug-induced thrombocytopenia
  • Systemic autoimmune disorders and immune dysregulation syndromes (secondary ITP)
    • Systemic lupus erythematosus
    • Autoimmune lymphoproliferative syndrome
    • Antiphospholipid antibody syndrome
    • Common variable immunodeficiency
    • DiGeorge (22q11.2 deletion) syndrome

Platelet activation and consumption

  • Microangiopathic disorders
    • Hemolytic-uremic syndrome
    • Thrombotic thrombocytopenic purpura
    • Disseminated intravascular coagulation
  • Major surgery or trauma
  • Kasabach-Merritt syndrome

Mechanical destruction

  • Extracorporeal therapies (eg, cardiopulmonary bypass)

Sequestration and trapping

  • Hypersplenism
  • Type 2B or platelet-type von Willebrand disease
Infection
  • Epstein-Barr virus, cytomegalovirus, bacterial sepsis, parvovirus, varicella, rickettsia, dengue virus

Nutritional deficiencies

  • Folate, B12, iron

Acquired bone marrow failure

  • Aplastic anemia
  • Myelodysplastic syndromes
  • Medications (eg, chemotherapy)
  • Radiation

Infiltrative bone marrow diseases

  • Leukemias
  • Lymphomas
  • Metastatic cancers
  • Infectious granulomas
  • Storage diseases

Genetic causes of impaired thrombopoiesis*

  • Wiskott-Aldrich syndrome/X-linked thrombocytopenia
  • Inherited bone marrow failure syndromes
    • Fanconi anemia
    • Dyskeratosis congenita
    • Shwachman-Diamond syndrome
    • Congenital amegakaryocytic thrombocytopenia
  • Thrombocytopenia with absent radii syndrome
  • Amegakaryocytic thrombocytopenia with radioulnar synostosis
  • Familial platelet disorder with predisposition to hematologic malignancy
  • Bernard-Soulier syndrome
  • MYH9-related disorders
  • Paris-Trousseau syndrome
  • X-linked thrombocytopenia with dyserythropoiesis

MYH9: nonmuscle myosin heavy chain gene.

* This is a partial list. For further details, refer to UpToDate topics on causes of thrombocytopenia in children and disorders of platelet function.
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