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خرید پکیج
تعداد آیتم قابل مشاهده باقیمانده : 3 مورد
نسخه الکترونیک
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Causes of high plasma D-dimer

Causes of high plasma D-dimer
Condition Mechanism
Thromboembolism:
  • Arterial
    • Myocardial infarction
    • Stroke
    • Acute limb ischemia
    • Intracardiac thrombus
  • Venous
    • Deep vein thrombosis
    • Pulmonary embolism
  • Disseminated intravascular coagulation (DIC)
Intravascular thrombosis and fibrinolysis
Inflammation:
  • COVID-19
  • Other severe infections
  • Sepsis
  • DIC
Activation of the acute inflammatory response and coagulation pathway, intravascular thrombosis and fibrinolysis
Surgery/trauma Tissue ischemia, tissue necrosis
Liver disease Reduced clearance of fibrin degradation products
Kidney disease Multiple, including renal vein thrombosis and nephrotic syndrome
Vascular disorders:
  • Vascular malformations
  • Sickle cell disease vaso-occlusion
Intravascular thrombosis and fibrinolysis
Malignancy Multiple, including vascular abnormalities, cancer procoagulant, and microvascular thrombosis
Thrombolytic therapy Fibrin breakdown
Pregnancy:
  • Normal pregnancy
  • Preeclampsia and eclampsia

Physiologic changes in the coagulation system

Microvascular thrombosis and fibrin deposition
Plasma D-dimer is a product of clot breakdown, released upon degradation of polymerized, crosslinked fibrin (if non-crosslinked fibrinogen was degraded, D-monomers would be released). Elevated plasma D-dimer levels indicate that coagulation has been activated, fibrin clot has formed, and clot degradation by plasmin has occurred. There are many causes of elevated D-dimer; identification of the underlying cause requires correlation with other findings, including the clinical picture and other laboratory results. Refer to UpToDate for further explanation of fibrinogen domain structure and pathophysiology of the disorders listed here.
COVID-19: coronavirus disease 2019; DIC: disseminated intravascular coagulation.
Graphic 60881 Version 5.0

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