Some agents capable of causing perioperative anaphylaxis and proposed mechanisms

Agents	Immunologic reactions		Nonimmunologic
Agents	IgE-mediated	Non-IgE-mediated	Nonimmunologic
Neuromuscular-blocking agents	+	–	+
Antibiotics	+ (eg, beta-lactams)	+/–	+ (eg, vancomycin)
Chlorhexidine	+	+/–	–
Blue dyes (aka vital dyes)	+	–	+/–
Hypnotic induction agents:
Barbiturates	+	+	+
Nonbarbiturates	+/–	+	+
Opioids	+/–	–	+
Colloids and plasma expanders	+	+	+
Sugammadex	+	–	+/–
Latex	+	–	–

+/–: agent may cause anaphylaxis by this mechanism.

IgE: immunoglobulin E.

Graphic 60805 Version 16.0

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