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تعداد آیتم قابل مشاهده باقیمانده : 3 مورد
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Urea cycle (UC)

Urea cycle (UC)
The flow of nitrogen intermediates in the urea cycle (UC) is depicted above. The UC converts nitrogen, derived from dietary protein intake and the breakdown of endogenous protein (catabolism), into urea, which can be excreted from the body. The steps of this cycle, and the six enzymes involved, are indicated in red. The dashed red arrow depicts the overflow of excess carbamyl phosphate (CP) into pyrimidine synthesis and, hence, to orotic acid, which is excreted in the urine. The dashed green arrow depicts the generation of nitric oxide (NO) when arginine is converted into citrulline by nitric oxide synthase (NOS). The green cylinders denote the ornithine and citrulline transporter (ORNT1; SLC25A15), and the blue cylinders represent the cationic amino-acid transporter found on intestinal- and kidney-epithelial cells (SLC7A7). The pink cylinder denotes citrin, a mitochondrial aspartate and glutamate transporter (SLC25A13).
ARG1: arginase; ASL: argininosuccinate lyase; ASS: argininosuccinate synthetase; CPS-I: carbamyl-phosphate-synthetase-I; NAG: N-acetylglutamate; NAGS: N-acetyl-glutamate synthase; OTC: ornithine transcarbamylase.
Courtesy of Brendan Lee, MD, PhD.
Graphic 60652 Version 2.0

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