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Recommended doses of formulations of hepatitis B vaccines licensed in the United States for infants, children, and adolescents younger than 18 years, by vaccine type and age group*

Recommended doses of formulations of hepatitis B vaccines licensed in the United States for infants, children, and adolescents younger than 18 years, by vaccine type and age group*
  Age group Volume (mL) Dose HBsAg (mcg)
Single-antigen vaccines
Recombivax HB
  • Pediatric/adolescent formulation
Birth through 17 years 0.5 5
  • Adult formulationΔ
11 through 15 years 1 10
Engerix B Birth through 17 years 0.5 10
Combination vaccines
Pediarix (combined HepB-DTaP-IPV) 6 weeks through 6 years 0.5 10
Vaxelis (combined HepB-DTaP-IPV-Hib 6 weeks through 4 years 0.5   10 
HBsAg: hepatitis B surface antigen; HepB: hepatitis B; DTaP: diphtheria, tetanus, acellular pertussis; IPV: inactivated poliovirus; Hib: Haemophilus influenzae type B.
* For recommended doses for persons ≥18 years, refer to UpToDate topic on HepB vaccines for adults.
¶ Administered on a 3- or 4-dose schedule. Refer to UpToDate topic on HepB vaccines for infants, children, and adolescents.
Δ Administered on a 2-dose schedule at 0 and 4 to 6 months. Both doses must be administered before the 16th birthday.
Typically administered at 2, 4, and 6 months of age.
Adapted from: Schillie S, Vellozzi C, Reingold A, et al. Prevention of hepatitis B virus infection in the United States: Recommendations of the Advisory Committee on Immunization Practices. MMWR Recomm Rep 2018; 67:1.
Additional data from: Vaxelis (Diphtheria and tetanus toxoids and acellular pertussis adsorbed, inactivated poliovirus, Haemophilus b conjugate [meningococcal protein conjugate] and hepatitis B [recombinant] vaccine. United States Prescribing Information. Revised December, 2018. US Food & Drug Administration. Available online: www.fda.gov/BiologicsBloodVaccines/ucm629107.htm (Accessed on December 28, 2018).
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