WHO classification of the non-Hodgkin lymphomas (subclassified according to clinical aggressiveness*)

The indolent lymphomas

B-cell neoplasms

Small lymphocytic lymphoma/B-cell chronic lymphocytic leukemia

Lymphoplasmacytic lymphoma (± Waldenstrom's macroglobulinemia)

Plasma cell myeloma/plasmacytoma

Hairy cell leukemia

Follicular lymphoma (grade I and II)

Marginal zone B-cell lymphoma

Mantle cell lymphoma^¶

T-cell neoplasms

T-cell large granular lymphocyte leukemia

Mycosis fungoides

T-cell prolymphocytic leukemia

Natural killer cell neoplasms

Natural killer cell large granular lymphocyte leukemia

The aggressive lymphomas

B-cell neoplasms

Follicular lymphoma (grade III)

Diffuse large B-cell lymphoma

Mantle cell lymphoma^¶

T-cell neoplasms

Peripheral T-cell lymphoma

Anaplastic large cell lymphoma, T/null cell

The highly aggressive lymphomas

B-cell neoplasms

Burkitt's lymphoma

Precursor B lymphoblastic leukemia/lymphoma

T-cell neoplasms

Adult T-cell lymphoma/leukemia

Precursor T lymphoblastic leukemia/lymphoma

* Editor's note: The WHO classification system of non-Hodgkin lymphoma (NHL) is presented here, subclassified according to the degree of clinical aggressiveness (ie, indolent, aggressive, highly aggressive) shown by each variant.
¶ Mantle cell lymphoma can behave clinically as either an indolent or an aggressive disorder.

Adapted from Harris, NL, Jaffe, ES, Diebold, J, et al. World Health Organization classification of neoplastic diseases of the hematopoietic and lymphoid tissues: Report of the Clinical Advisory Committee meeting-Airlie House, Virginia, November 1997. J Clin Oncol 1999; 17:3835.

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WHO classification of the non-Hodgkin lymphomas (subclassified according to clinical aggressiveness*)