Select toxic agents causing coma

Toxic agent	Features which may distinguish from opioids
Antihistamines	Anticholinergic toxidrome
Antipsychotics	Pupils, bowel sounds normal
Barbiturates	Mild to severe hypotension, serum concentration
β-adrenergic antagonists	Cardiovascular findings (hypotension, bradycardia) more prominent than mental status findings
Calcium channel blockers	Cardiovascular findings (hypotension, bradycardia, or tachycardia) more prominent than mental status findings
Carbamazepine	Serum concentration
Carbon monoxide	Carboxyhemoglobin level
Clonidine	Bradycardia, hypotension
Cyclic antidepressants	QRS prolongation, hypotension, tachycardia
Ethanol	Pupils, bowel sounds normal, serum concentration
Ethylene glycol	Pupils, bowel sounds normal
Hypoglycemic agents	Serum glucose concentration
Isoniazid	History of seizures, normal pupils, bowel sounds
Isopropanol	Pupils, bowel sounds normal
Lithium	Tremor, hyperreflexia, serum concentration
Methanol	Pupils, bowel sounds normal
Organic-phosphorous compounds	Cholinergic toxidrome
Phencyclidine	Nystagmus (horizontal, vertical, or rotary)
Sedative-hypnotic agents	Pupil size normal to decreased, bowel sounds normal, less respiratory depression

Drugs_causing_coma.htm

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