Brain MRI and MR spectroscopy (MRS) of a 5-year-old with Sjögren-Larsson syndrome

(A) Image shows voxel locations in the occipital trigone (square) and in the central occipital gray matter (circle).

(B) Proton MR spectra (TE = 20 msec) obtained from cerebral white matter (spectrum C) and gray matter (spectrum D). Note the presence of the high, sharp lipid peak at 1.3 ppm and a small peak at 0.8 to 0.9 ppm in the spectrum obtained from the white matter.

MR: magnetic resonance; TE: echo time.

Reproduced with permission from: Willemsen MA, Van Der Graaf M, Van Der Knaap MS, et al. MR imaging and proton MR spectroscopic studies in Sjögren-Larsson syndrome: characterization of the leukoencephalopathy. AJNR Am J Neuroradiol 2004; 25:649. Copyright ©2004 American Society of Neuroradiology.

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Brain MRI and MR spectroscopy (MRS) of a 5-year-old with Sjögren-Larsson syndrome