Cairo-Bishop definition of laboratory tumor lysis syndrome

Element	Value	Change from baseline
Uric acid	≥476 micromol/L (8 mg/dL)	25% increase
Potassium	≥6.0 mmol/L (or 6 mEq/L)	25% increase
Phosphorus	≥2.1 mmol/L (6.5 mg/dL) for children or ≥1.45 mmol/L (4.5 mg/dL) for adults	25% increase
Calcium	≤1.75 mmol/L (7 mg/dL)	25% decrease

NOTE: Two or more laboratory changes within three days before or seven days after cytotoxic therapy.

Reproduced with permission from: Coiffier B, Altman A, Pui CH, et al. Guidelines for the management of pediatric and adult tumor lysis syndrome: an evidence-based review. J Clin Oncol 2008; 26:2767. Copyright ©2008 American Society of Clinical Oncology. All rights reserved.

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Cairo-Bishop definition of laboratory tumor lysis syndrome