Version May 2024
| Comorbidity | Charlson comorbidity index (CCI) definition | CCI score | Hematopoietic cell transplantation-specific comorbidity index (HCT-CI) definition | HCT-CI score |
| Pulmonary disease | ||||
| Mild | Dyspnea on moderate activity (or with asthma attacks) | 1 | Dyspnea on moderate activity or DLCO and/or FEV1 81 to 90% | 0 |
| Moderate | Dyspnea on slight activity | 1 | Dyspnea on slight activity or DLCO and/or FEV1 66 to 80% | 2 |
| Severe | Dyspnea at rest or requires oxygen | 1 | Dyspnea at rest or requires oxygen or DLCO and/or FEV1 ≤65% | 3 |
| Cardiac disease | ||||
| General | Congestive heart failure (symptomatic and requiring treatment) and myocardial infarction were included as independent comorbidities, each acquiring a score of 1 | 1 or 2 | Coronary artery disease*, congestive heart failure, myocardial infarction, or EF ≤50% | 1 |
| Arrhythmia | N/A | 0 | Atrial fibrillation or flutter, sick sinus syndrome, or ventricular arrhythmias | 1 |
| Heart valve disease | Except mitral valve prolapse | 0 | Except mitral valve prolapse | 3 |
| Hepatic disease | ||||
| Mild | Chronic hepatitis or cirrhosis | 1 | Chronic hepatitis, bilirubin >ULN to 1.5 × ULN, or AST/ALT >ULN to 2.5 × ULN | 1 |
| Moderate to severe | Cirrhosis with portal hypertension ± bleeding varices | 3 | Cirrhosis or fibrosis or bilirubin >1.5 × ULN or AST/ALT >2.5 × ULN | 3 |
| Renal disease | ||||
| Mild | Serum creatinine 2 to 3 mg/dL | 0 | Creatinine 1.2 to 2 mg/dL | 0 |
| Moderate to severe | Creatinine >3 mg/dL, renal dialysis, or renal transplant | 2 | Creatinine >2 mg/dL, renal dialysis, or renal transplant | 2 |
| Other malignancies | ||||
| Prior solid tumor | Initially treated in the last 5 years | 2 | Treated at any time point in the patient's history, excluding nonmelanoma skin cancer | 3 |
| Metastatic cancer | Present | 6 | Not included | N/A |
| Other comorbidities | ||||
| Diabetes | Requiring treatment with insulin or oral hypoglycemics but not diet alone | 1 | Requiring treatment with insulin or oral hypoglycemics but not diet alone | 1 |
| Cerebrovascular disease | Transient ischemic attack or cerebrovascular accident | 1 | Transient ischemic attack or cerebrovascular accident | 1 |
| Rheumatologic | SLE, RA, polymyositis, mixed CTD, or polymyalgia rheumatica | 1 | SLE, RA, polymyositis, mixed CTD, or polymyalgia rheumatica | 2 |
| Peptic ulcer | Requiring treatment | 1 | Requiring treatment | 2 |
| Psychiatric disturbance | Not included | N/A | Depression or anxiety requiring psychiatric consult or treatment | 1 |
| Infection | Not included | N/A | Requiring continuation of antimicrobial treatment after day 0 | 1 |
| Inflammatory bowel disease | Not included | N/A | Crohn disease or ulcerative colitis | 1 |
| Obesity | Not included | N/A | Patients with a body mass index >35 kg/m2 | 1 |
DLCO: diffusion capacity of carbon monoxide; FEV1: forced expiratory volume in one second; EF: ejection fraction; ULN: upper limit of normal; AST: aspartate aminotransferase; ALT: alanine aminotransferase; SLE: systemic lupus erythematosus; RA: rheumatoid arthritis; CTD: connective tissue disease.
* One or more vessel-coronary artery stenosis requiring medical treatment, stent, or bypass graft.آیا می خواهید مدیلیب را به صفحه اصلی خود اضافه کنید؟
