Version May 2024
| Symptoms and signs by system involved |
| Allergic: food allergy, rash |
| Dermatologic: erythema, vesiculations from burns, lacerations, scratches, puncture wounds, eczema |
| Developmental: learning disabilities, attention-deficit/ hyperactivity disorders, neuromotor dysfunctions, pervasive developmental delay, psychosis |
| Endocrine: polydipsia, polyuria, hypoglycemia, diabetes, glycosuria |
| Gastrointestinal: abdominal pain, anorexia, diarrhea, dehydration, esophageal burns, vomiting, weight loss, bowel obstruction, gut dyskinesias, bleeding including hematemesis and hematochezia or melena, bleeding from nasogastric tube, bleeding from ileostomy, disorders leading to a need for parenteral nutrition |
| Hematologic: bleeding, easy bruising, anemia |
| Infection: fever, leukopenia, sepsis, septic arthritis, osteomyelitis; failure to resolve infections with antibiotics to which bacteria are susceptible; onset of new infection while the child is receiving antibiotics to which the bacteria are susceptible; unusual bacteria from the site of infection or infection with multiple simultaneous organisms of low pathogenicity |
| Metabolic: mitochondrial disorders, without positive testing |
| Neurologic: seizures, headaches, weakness, disorder of consciousness |
| Oncologic: leukemia, other cancers |
| Ophthalmic: recurrent hemorrhagic conjunctivitis, keratitis, eyelid swelling, unequal pupils, nystagmus, periorbital cellulitis |
| Orthopedic: limping |
| Otic: otorrhea, recurrent infections |
| Renal: hematuria, proteinuria, renal calculi, bacteriuria, renal insufficiency, hypertension, nocturia, hypernatremia, hyponatremia, hypokalemia, pyuria, renal failure |
| Respiratory: presentation with an acute life-threatening event, apnea including sleep apnea, cystic fibrosis, bleeding from the upper respiratory tract, intractable asthma, hemoptysis, cyanosis, hypoxia |
| Rheumatologic: arthritis, arthralgia, morning stiffness |
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