Causes of gestational hyperandrogenism*

Luteoma

Theca lutein cysts

Exogenous androgen administration

Placental aromatase deficiency

Sertoli-Leydig cell tumor

Other ovarian tumors

Krukenberg tumors (gastrointestinal cancer metastatic to ovaries)

Adrenal tumors (adenomas and carcinomas)

* Does not include causes of hyperandrogenism that pre-date pregnancy, including polycystic ovary syndrome (PCOS) and congenital adrenal hyperplasia (CAH).

Adapted from: McClamrock HD, Adashi EY. Gestational hyperandrogenism. In: Reproductive Endocrinology, Surgery, and Technology, Adashi EY, Rock JA, Rosenwaks Z (Eds), Lippincott-Raven, Philadelphia, 1996, p. 612.

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