Version May 2024
| Surfactant | Origin | Concentration of phospholipids | Concentration of protein | Initial dose* | Repeat dosing schedule* |
| Poractant alfa (Curosurf) | Porcine lung minces, lipid extraction with purification using liquid-gel chromatography. | 76 mg PL per mL | 1 mg per mL (contains 0.45 mg/mL of SP-B and 0.59 mg/mL of SP-C) | 2.5 mL/kg (contains 190 mg/kg PL) | 1.25 mL/kg (95 mg/kg PL) every 12 hours as needed up to two total doses. |
| Calfactant (Infasurf) | Calf lung lavage, lipid extraction. | 35 mg PL per mL | 0.7 mg per mL (contains 0.26 mg/mL of SP-B and 0.44 mg/mL of SP-C) | 3 mL/kg (contains 105 mg/kg PL) | 3 mL/kg (105 mg/kg PL) every 12 hours as needed up to three total doses. |
| Beractant (Survanta) | Bovine lung minces, lipid extraction. Supplemented with DPPC, palmitic acid, and tripalmitin. | 25 mg PL per mL | <1 mg per mL (contains both SP-B and SP-C) | 4 mL/kg (contains 100 mg/kg PL) | Repeat same dose every six hours as needed for total of four doses. |
| Bovine lipid extract surfactant (BLES, available in Canada) | Extract of natural bovine lung surfactant. | 27 mg PL per mL | 0.2 to 0.5 mg per mL (contains both SP-B and SP-C) | 5 mL/kg (contains 135 mg/kg PL) | Repeat same dose as needed up to a maximum of four doses within the first five days of life. |
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