Receptor | Major ligands | Functions |
CR1 | C3b/C4b, C1q, MBL, ficolins | Immune adherence; immune complex clearance; regulation of C3b/C4b |
CR2 | iC3b, C3dg, C3d, IgE receptor, interferon alpha, DNA | B cell coreceptor; immune complex localization; EBV receptor; presents complement-opsonized antigens to T cells |
CR3 | iC3b, clotting factor X and up to 50 other ligands | Phagocytosis; neutrophil activation; apoptosis; cell activation |
CR4 | iC3b/fibrinogen/ICAMs | Phagocytosis; cell activation |
C3aR | C3a | Cell type dependent; cell activation; histamine release |
C4aR | C4a | Cell activation; endothelial cell permeability |
C5aR1 | C5a | Cell activation; chemotaxis; development and regeneration |
C5aR2 | C5a | Possible functions include nonsignaling decoy receptor; modulator of C5aR1; G-protein independent signaling |
C1qR* | C1q* | Phagocytosis; a variety of C1q receptors have been identified with varied functions* |
CRIg | C3b/iC3b | Phagocytosis; alternative pathway inhibitor |
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