Deficient intake or absorption |
Dietary |
Malabsorption |
Gastric bypass (bariatric surgery, gastrectomy) |
Small bowel disease |
Pancreatic insufficiency |
Decreased skin synthesis |
Inadequate sunlight exposure |
Full sunscreen use |
Darkly pigmented skin |
Defective 25-hydroxylation |
Cirrhosis |
Obesity (possibly) |
Increased catabolism of vitamin D to inactive metabolites |
Antiseizure medications |
Loss of vitamin D binding protein |
Nephrotic syndrome |
Defective 1-alpha 25-hydroxylation |
Hypoparathyroidism |
Kidney failure |
1-alpha hydroxylase deficiency (vitamin D-dependent rickets, type 1) |
Defective target organ response to calcitriol |
Hereditary vitamin D-resistant rickets (vitamin D-dependent rickets, type 2) |
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