- Mechanism of production of aerosol
- Residual volume
- Flow rate
- Fill volume
- Solution/suspension characteristics
- Driving gas characteristics
- Designs to enhance output
- Continuous versus intermittent delivery
- Proper maintenance of compressor and nebulizer
| - Breathing pattern
- Nose versus mouth breathing
- Age
- Cooperation
- Artificial airway
- Airway obstruction
- Concomitant use with airway clearance device
- Used while receiving ventilator support
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