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Estimated* increase in infant blood lead concentration associated with different maternal blood lead concentrations at 1 month postpartum

Estimated* increase in infant blood lead concentration associated with different maternal blood lead concentrations at 1 month postpartum
Maternal blood lead concentration (µg/dL) Estimated breast milk lead concentration (µg/L) Estimated associated increase in infant blood lead at age 1 month (µg/dL)Δ
1 0.3 0.12
2 0.6 0.25
3 0.9 0.37
4 1.2 0.49
5 1.5 0.62
8 2.4 0.98
10 3 1.2
20 6 2.5
30 9 3.7
40◊ 12 4.9
* This estimation integrates absorption, distribution, and excretion.
¶ These values are estimations based upon ICP-MS laboratory analysis and increments of less than 2 μg/dL would not necessarily be detectable in clinical laboratories.
Δ Calculated based upon the observation that a 2 μg/L increase in breast milk lead is associated with an increase of 0.82 μg/dL in the blood lead of the nursing infant[1].
◊ Extrapolation beyond the range of observed data from Ettinger et al 2004[1] (where maternal BLLs ranged from 1-30 μg/dL).
Reference:
  1. Ettinger AS, Tellez-Rojo MM, Amarasiriwardena C, et al. Effect of breast milk lead on infant blood lead levels at 1 month of age. Environ Health Perspect 2004; 112:1381.
Reproduced from: Ettinger AS, Gurthrie Wengrovitz A (Eds). Guidelines for the identification and management of lead exposure in pregnant and lactating women. National Center for Environmental Health/Agency for Toxic Substances and Disease Registry; Centers for Disease Control and Prevention, Atlanta, GA, 2010. Available at http://www.cdc.gov/nceh/lead/publications/LeadandPregnancy2010.pdf.
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