ﺑﺎﺯﮔﺸﺖ ﺑﻪ ﺻﻔﺤﻪ ﻗﺒﻠﯽ
خرید پکیج
تعداد آیتم قابل مشاهده باقیمانده : 3 مورد
نسخه الکترونیک
medimedia.ir

Chemotherapy-associated ovarian toxicity

Chemotherapy-associated ovarian toxicity
Drug Class (action)
Definitely associated with ovarian damage
Nitrogen mustard Mechlorethamine (alkylating agent)
L-phenylalanine mustard Mechlorethamine (alkylating agent)
Chlorambucil Chloroethylamine (alkylating agent)
Cyclophosphamide Chloroethylamine (alkylating agent)
Melphalan Mechlorethamine (alkylating agent)
Busulfan Alkylalkane sulfonate (alkylating agent)
Procarbazine Substituted hydrazine
Dacarbazine Alkylating agent
Doxorubicin Anthracycline
Probably associated with ovarian damage
Cis-platinum Heavy metal
Carmustine Nitrosourea (alkylating agent)
Lomustine Nitrosourea (alkylating agent)
Daunorubicin Anthracycline
Low probability of ovarian damage
Methotrexate Antimetabolite
Fluorouracil (5-FU) Antimetabolite
6-mercaptopurine Antimetabolite
Vincristine Vinca alkaloid
Mitomycin Antibiotic (alkylating agent)
Bleomycin Peptide
Vinblastine Vinca alkaloid
Cytosine arabinoside (Ara-C) Antimetabolite
VP-16 (etoposide) Podophyllotoxin
Imatinib Tyrosine kinase inhibitor
Unknown
VM-26 Podophyllotoxin
Vindesine Vinca alkaloid
Data from:
  1. Park JY, Kim DY, Suh DS, et al. Outcomes of pediatric and adolescent girls with malignant ovarian germ cell tumors. Gynecol Oncol 2015;137:418.
  2. Goldfarb SB, Turan V, Bedoschi G, et al. Impact of adjuvant chemotherapy or tamoxifen-alone on the ovarian reserve of young women with breast cancer. Breast Cancer Res Treat 2021;185:165.
  3. Szymanska KJ, Tan X, Oktay K. Unraveling the mechanisms of chemotherapy-induced damage to human primordial follicle reserve: road to developing therapeutics for fertility preservation and reversing ovarian aging. Mol Hum Reprod 2020; 26:553.
  4. Soleimani R, Heytens E, Darzynkiewicz Z, Oktay K. Mechanisms of chemotherapy-induced human ovarian aging: double strand DNA breaks and microvascular compromise. Aging 2011; 3:782.
Graphic 58142 Version 14.0

آیا می خواهید مدیلیب را به صفحه اصلی خود اضافه کنید؟