Disorders of extracellular calcium-sensing by the CaSR

Disorders with generalized decrease in sensitivity to Ca²⁺ (affecting all CaSR-expressing tissue)

FHH

NHPT and NSHPT

Familial isolated hyperparathyroidism caused by CaSR mutations

Autoimmune hypocalciuric hypercalcemia

Disorders with parathyroid-specific decrease in sensitivity to Ca²⁺

Primary hyperparathyroidism

Severe uremic secondary and tertiary hyperparathyroidism

Disorders with generalized increase in sensitivity to Ca²⁺

ADH due to activating CaSR mutations

ADH with features of Bartter syndrome

Hypoparathyroidism due to activating antibodies to the CaSR

CaSR: calcium-sensing receptor; Ca: calcium; FHH: familial hypocalciuric hypercalcemia; NHPT: neonatal hyperparathyroidism; NSHPT: neonatal severe hyperparathyroidism; ADH: autosomal dominant hypoparathyroidism.

Graphic 58108 Version 4.0

خرید پکیج

Disorders of extracellular calcium-sensing by the CaSR