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Relative risks of major complications of chronic kidney disease based upon a continuous meta-analysis

Relative risks of major complications of chronic kidney disease based upon a continuous meta-analysis
Summary of continuous meta-analysis (adjusted RR) for general population cohorts with ACR. Mortality is reported for general population cohorts assessing albuminuria as urine ACR. Kidney outcomes are reported for general population cohorts assessing albuminuria as either urine ACR or dipstick. eGFR is expressed as a continuous variable. The three lines represent urine ACR of <30 mg/g or dipstick negative and trace (blue), urine ACR 30-299 mg/g or dipstick 1+ positive (green), and urine ACR >300 mg/g or dipstick >2+ positive (red). All results are adjusted for covariates and compared with reference point of eGFR of 95 mL/min per 1.73 m2 and ACR of <30 mg/g or dipstick negative (diamond). Each point represents the pooled RR from a meta-analysis. Solid circles indicate statistical significance compared with the reference point (p<0.05); triangles indicate non-significance. Red arrows indicate eGFR of 60 mL/min per 1.73 m2, threshold value of eGFR for the current definition of CKD.
CKD: chronic kidney disease; ACR: albumin creatinine ratio; HR: hazard ratio; eGFR: estimated glomerular filtration rate; RR: relative risk.
Reprinted by Permission from Macmillan Publishers Ltd: Levey AS, de Jong PE, Coresh J, et al. The definition, classification, and prognosis of chronic kidney disease: a KDIGO Controversies Conference report. Kidney Int 2010; 80:17. Copyright © 2010.
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