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تعداد آیتم قابل مشاهده باقیمانده : 3 مورد
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Presenting features of 78 consecutive patients with immune TTP

Presenting features of 78 consecutive patients with immune TTP
Signs and symptoms Number affected*
Microangiopathic hemolytic anemia (MAHA) 78 (100%)
Thrombocytopenia 78 (100%)
Neurologic abnormalities
  • Severe (coma, stroke, seizure, focal signs)
 41 (53%)
  • Minor (confusion, headache)
 21 (27%)
  • No neurologic abnormalities
 16 (20%)
Kidney function abnormalities
  • Acute kidney failure
 4 (5%)
  • Reduced kidney function
 37 (47%)
  • Normal kidney function
 37 (47%)
Fever 8 (10%)
Refer to UpToDate for additional details.
TTP: thrombotic thrombocytopenic purpura; MAHA: microangiopathic hemolytic anemia.
* Data are from the day of diagnosis, defined as the day of the first therapeutic plasma exchange. ADAMTS13 activity was <10% of normal in all cases.
¶ Acute kidney failure was defined as an increased serum creatinine of ≥0.5 mg/dL/day for two consecutive days or a serum creatinine of ≥4.0 mg/dL with hemodialysis.
Data from: Page EE, Kremer Hovinga JA, Terrell DR, et al. Thrombotic thrombocytopenic purpura: Diagnostic criteria, clinical features, and long-term outcomes from 1995 through 2015. Blood Advances 2017; 1:590.
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