NCI CTCAE v5.0 infusion-related reactions

Adverse event	Grade 1	Grade 2	Grade 3	Grade 4	Grade 5
Infusion related reaction	Mild transient reaction; infusion interruption not indicated; intervention not indicated	Therapy or infusion interruption indicated but responds promptly to symptomatic treatment (eg, antihistamines, NSAIDs, narcotics [opioids], intravenous fluids); prophylactic medication indicated for less than or equal to 24 hours	Prolonged (eg, not rapidly responsive to symptomatic medication and/or brief interruption of infusion); recurrence of symptoms following initial improvement; hospitalization indicated for other clinical sequelae	Life-threatening consequences; urgent intervention indicated	Death

Infusion-related reaction is characterized by adverse reaction to the infusion of pharmacological or biological substances.

NCI CTCAE: National Cancer Institute Common Terminology Criteria for Adverse Events; NSAIDs: nonsteroidal anti-inflammatory drugs.

Reproduced from: Common Terminology Criteria for Adverse Events (CTCAE), Version 5.0, November 2017, National Institutes of Health, National Cancer Institute. Available at: https://ctep.cancer.gov/protocoldevelopment/electronic_applications/docs/CTCAE_v5_Quick_Reference_8.5x11.pdf (Accessed March 27, 2018).

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