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Prevalence of human herpesvirus 6 (HHV-6) infection in young children

Prevalence of human herpesvirus 6 (HHV-6) infection in young children
Geometric mean anti-HHV-6 antibody titers (blue) and the proportion with HHV-6 DNA detected by PCR in peripheral blood mononuclear cells (red) in 2427 infants and young children under the age of three years. Children with an acute febrile illness due to HHV-6 were excluded. HHV-6 DNA was detected in 10 percent of infants less than one month of age, which is consistent with perinatal transmission, and in 66 percent at one year. The rate of seroconversion was highest between 6 and 12 months of age; the high titers present in the first few months represent maternal antibodies.
PCR: polymerase chain reaction.
Adapted from: Hall CB, Long CE, Schnabel KC, et al. Human herpesvirus-6 infection in children. A prospective study of complications and reactivation. N Engl J Med 1994; 331:432.
Graphic 57693 Version 5.0

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