Nonantimicrobial sulfonamides that are generally tolerated in patients who are allergic to sulfonamide antibiotics

Loop diuretics

Bumetanide*

Furosemide*

Torsemide*

Thiazide and related diuretics

Hydrochlorothiazide*

Chlorothiazide*

Chlorthalidone*

Indapamide*

Methyclothiazide*

Metolazone*

Sulfonylurea hypoglycemics

Glyburide

Glipizide

Glimepiride

Chlorpropamide

Tolazamide

Carbonic anhydrase inhibitors

Acetazolamide*

Brinzolamide ophthalmic*

Dorzolamide ophthalmic*

Methazolamide*

HIV and HCV protease inhibitors

Amprenavir*

Fosamprenavir*

Darunavir*

Simeprevir*

Other

Celecoxib*

Diazoxide*

Ibutilide

Probenecid^¶

Sotalol

Sumatriptan

Tipranavir*

Topiramate

Zonisamide*

Despite warnings of potential for cross-reaction contained in the manufacturers' labeling of the nonantimicrobial sulfonamides listed in this table, there is minimal evidence for cross-reactivity for these agents in patients who are allergic to sulfonamide antimicrobials.
Sulfasalazine is an exception and can cause a cross-reaction in patients with allergies to sulfonamide antimicrobials because it releases sulfapyridine (a cross-reactive arylamine sulfonamide) in contact with gut flora. Thus, use of sulfasalazine is contraindicated in patients with a significant allergy to sulfonamide antimicrobials.

HIV: human immunodeficiency virus; HCV: chronic hepatitis C virus infection; G6PD: glucose-6-phosphate dehydrogenase.
* US Food and Drug Administration (FDA)-approved product information for this drug contains cautionary statement(s) regarding use in patients with history of allergy to sulfonamide drugs. However, clear evidence of cross-reactivity to nonantimicrobial drugs listed in this table among patients with a history of hypersensitivity to sulfonamide antibiotics is lacking, except sulfasalazine.
¶ High risk in G6PD deficiency. See: http://www.g6pd.org/.

Prepared with data from: US Food and Drug Administration (FDA)-approved product information. US National Library of Medicine. (Available online at: https://dailymed.nlm.nih.gov/dailymed/about.cfm). Accessed May 30, 2014.

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Nonantimicrobial sulfonamides that are generally tolerated in patients who are allergic to sulfonamide antibiotics