Version May 2024
| Stage I |
| Low cell mass: <0.6 × 1012 cells/m2 PLUS all of the following: |
| Hb >10 g/dL |
| Serum IgG <5 g/dL |
| Serum IgA <3 g/dL |
| Normal serum calcium |
| Urine monoclonal protein excretion <4 g/day |
| No generalized lytic bone lesions |
| Stage II |
| Intermediate cell mass: neither stage I nor stage III |
| Stage III |
| High cell mass: >1.2 × 1012 cells/m2 PLUS one of more of the following: |
| Hb <8.5 g/dL |
| Serum IgG >7 g/dL |
| Serum IgA >5 g/dL |
| Serum calcium >12 mg/dL (3 mmol/L) |
| Urine monoclonal protein excretion >12 g/day |
| Advanced lytic bone lesions |
| Stage III is subclassified as IIIA or IIIB based on serum creatinine |
| A. Serum creatinine <2 mg/dL (177 μmol/L) |
| B. Serum creatinine ≥2 mg/dL |
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