I. Periportal± bridging necrosis | Score | II. Intralobular degeneration and focal necrosis¶ | Score | III. Portal inflammation | Score | IV. Fibrosis | Score |
None | 0 | None | 0 | No portal inflammation | 0 | No fibrosis | 0 |
Mild piecemeal necrosis | 1 | Mild (acidophilic bodies, ballooning degeneration and/or scattered foci of hepatocellular necrosis in <1/3 of lobules or nodules | 1 | Mild (sprinkling of inflammatory cells in <1/3 of portal tracts) | 1 | Fibrous portal expansion | 1 |
Moderate piecemeal necrosis (involves less than 50 percent of the circumference of most portal tracts) | 3 | Moderate (involvement of 1/3 to 2/3 of lobules or nodules) | 3 | Moderate (increased inflammatory cells in 1/3 to 2/3 of portal tracts) | 3 | Bridging fiborisis (portal-portal or portal-central linkage) | 3 |
Marked piecemeal necrosis (involves more than 50 percent of the circumference of most portal tracts) | 4 | Marked (involvement of >2/3 of lobules or nodules) | 4 | Marked (dense packing of inflammatory cells in >2/3 of portal tracts) | 4 | CirrhosisΔ | 4 |
Moderate piecemeal necrosis plus bridging necrosis◊ | 5 | ||||||
Marked piecemeal necrosis plus bridging necrosis◊ | 6 | ||||||
Multilobular necrosis§ | 10 |
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