Version July 2025
| Clinically significant, unintentional weight loss (>5% usual body weight over 6 to 12 months) |
| Overt gastrointestinal bleeding (eg, hematemesis, hematochezia, melena) |
| Dysphagia |
| Odynophagia |
| Unexplained iron deficiency anemia |
| Persistent vomiting |
| Palpable mass or lymphadenopathy |
| Family history of upper gastrointestinal cancer |
