Version May 2024
| Entity | Histology | Immunophenotype | Genetic features/other |
| Diffuse large B-cell lymphoma | Large, transformed B-cells with prominent nucleoli and basophilic cytoplasm, a diffuse growth pattern and a high proliferation (Ki-67+) fraction. | Generally express pan B-cell antigens (CD19, CD20, CD22, CD79a). | The majority has genetic abnormalities, but there is no single cytogenetic change that is typical or diagnostic. |
| Burkitt lymphoma | Monomorphic, medium-sized cells with round nuclei, multiple nucleoli, basophilic cytoplasm, prominent cytoplasmic lipid vacuoles, and a "starry-sky" pattern. Ki-67+ fraction approaching 100 percent. | Express surface IgM and B-cell-associated antigens (CD19, CD20, CD22, CD79a), as well as CD10, HLA-DR, and CD43. They lack CD5, bcl-2, and typically lack CD23. | Strongly (but not uniformly) associated with a translocation between the long arm of chromosome 8, the site of the c-MYC oncogene (8q24), and one of three locations on Ig genes: t(8;14), t(2;8), or t(8;22). |
| Anaplastic large cell lymphoma | Large cells with horseshoe-shaped or embryoid nuclei, prominent nucleoli, and abundant cytoplasm. Often shows a cohesive growth pattern. | Homogeneous and strong expression of CD30 in a membrane and golgi pattern. Usually express one or more T-cell antigens (ie, CD2, CD3, CD5, CD7). Do not express B-cell antigens. | Two distinct subtypes: ALK positive (detected by immunostains or molecular genetics) and ALK negative. |
| Hodgkin lymphoma | Lymphocyte predominant or lymphocyte rich classical Hodgkin lymphoma (HL) can morphologically resemble T-cell histiocyte rich large B-cell lymphoma. The HL tumor contains a minority of neoplastic cells (Reed-Sternberg cells and their variants) in an inflammatory background. | The neoplastic cells typically express CD15 and CD30, variably express CD20, and do not express CD3 or CD45. | There is no single cytogenetic change that is typical or diagnostic. |
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