Genetic and acquired risk factors for a first episode of venous thromboembolism (VTE)

Condition/risk factor(s)	Relative risk	Incidence (percent per year)
Baseline risk	1	0.008
Prothrombin G20210A mutation	2.8	0.02
Oral contraceptives	4	0.03
Factor V Leiden mutation (heterozygous)	7	0.06
Oral contraceptives plus heterozygous factor V Leiden mutation	35	0.29

Refer to UpToDate for further information. These risks were derived from the Leiden thrombophilia study; other studies have found slightly different risk estimates.

From Annals of Internal Medicine, Bauer KA, The thrombophilias: Well-defined risk factors with uncertain therapeutic implications, vol. 135, p. 367. Copyright © 2001 American College of Physicians, Inc.

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Genetic and acquired risk factors for a first episode of venous thromboembolism (VTE)