5-FU treatment of vaginal intraepithelial neoplasia

Author	Year	Patients treated	Recurred after first treatment (percent)	Treatment schedule	Follow-up range
Woodruff	1975	9	11	Twice a day for 1 month then monthly	6 weeks to 6 years
Piver	1979	8	38	Once a day for 5 days per month for 2 to 3 months	3 to 7 years
Ballon	1979	12	25	Twice a day for 2 weeks	6 to 30 months
Daly	1980	17	0	Twice a day for 10 to 14 days	2 to 5 years
Petrilli	1980	15	20	Twice a day for 5 days	2 to 60 months
Caglar	1981	27	15	Once a day for 5 to 10 days	3 to 48 months
Kirwan	1985	14	7	Every week for 10 weeks	4 to 42 months
Krebs	1989	37	19	Every week for 10 weeks	12 to 84 months
Audet-LaPointe	1990	12	17	Once a day for 5 days	9 to 42 months
Dodge	2001	22	59	Not reported	>7 months
Murta	2005	16	38	Every week for 10 weeks	Not reported
Fiascone	2017	47	26	Every week for 8 weeks	4 to 92 months

FU: fluorouracil.

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