Spectrum of immune compromise

Significantly immunocompromising conditions include:

Hematopoietic stem cell transplant (HCT) within the past two years

Solid organ transplant (SOT) within the past year

Treatment for rejection after SOT

Active leukemia or lymphoma

Generalized malignancy

Aplastic anemia

Graft-versus-host disease

Congenital immunodeficiency

Recent radiation therapy

Significantly immunosuppressive medications

AIDS with low CD4 count

Moderately immunocompromising conditions include:

Chronic hepatic disease (cirrhosis and alcoholism)

Chronic renal disease

Diabetes

Asplenia

Nutritional deficiencies (depending on the nature of the deficiency)

Minimally immunocompromising conditions include:

Chemotherapy for leukemia/lymphoma or cancer more than three months earlier

Malignancy in remission

High-dose steroid use more than a month earlier

Mild steroid use including inhaled, topical, intraarticular, bursal, or tendon injection

HIV with >500 CD4 lymphocytes/mm³

HCT recipients more than two years post-transplant who are not on immunosuppressive drugs and do not have graft-versus-host disease

Modified from: Kotton CN, et al. Immunocompromised Travelers. In: CDC Health Information for International Travel 2016: The Yellow Book.

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