The thrombopoietins (c-mpl-ligands)

First-generation thrombopoietins

rHuTPO (tpiao)

PEG-rHuMGDF

Second-generation thrombopoietins

Peptide TPO receptor agonists

Romiplostim (Nplate, Romiplate, AMG 531)

Non-peptide TPO receptor agonists

Eltrombopag (Promacta, Revolade, SB497115)

Avatrombopeg (Doptelet, E5501, YM-477, AKR-501)

Lusutrombopag (Mulpleta)

Hetrombopag

LGA-4665^*

NIP-004, NIP-022^*

Butyzamide^*

TPO receptor agonist antibodies (anti-Mpl antibody)

Minibodies (VB22 sc(Fv)2)^*

Domain subclass-converted TPO agonist antibodies (MA01G4G344)^*

Refer to UpToDate for information on mechanism of action and clinical use.

PEG-rHuMGDF: pegylated recombinant human megakaryocyte growth and development factor; rHuTPO: recombinant human TPO; TPO: thrombopoietin.

* These molecules have not been clinically developed.

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