Laboratory findings in the interstitial lung diseases

Abnormality	Associated condition
Leukopenia	Sarcoidosis; connective tissue disease; lymphoma; drug-induced
Leukocytosis	Hypersensitivity pneumonitis; lymphoma; systemic vasculitis
Eosinophilia	Eosinophilic pneumonia; sarcoidosis; systemic vasculitis; drug-induced (sulfa, methotrexate)
Thrombocytopenia	Sarcoidosis; connective tissue disease; drug-induced; Gaucher's disease
Hemolytic anemia	Connective tissue disease; sarcoidosis; lymphoma; drug-induced
Normocytic anemia	Diffuse alveolar hemorrhage syndromes; connective tissue disease; lymphangitic carcinomatosis
Hypercalcemia	Sarcoidosis; lymphangitic carcinomatosis
Urinary sediment abnormalities	Connective tissue disease; systemic vasculitis; drug-induced; systemic lupus erythematosis
Hypogammaglobulinemia	Lymphocytic interstitial pneumonitis
Hypergammaglobulinemia	Connective tissue disease; sarcoidosis; systemic vasculitis; lymphocytic interstitial pneumonia; lymphoma; silicosis
Anti-glomerular basement membrane antibody (anti-GBM)	Anti-GBM disease (Goodpasture disease)
Anti-neutrophil cytoplasmic antibody (ANCA)	Granulomatosis with polyangiitis (Wegener's); Eosinophilic granulomatosis with polyangiitis (Churg-Strauss); microscopic polyangiitis
Serum precipitating antibodies	Hypersensitivity pneumonitis
Lymphocyte transformation test	Chronic beryllium disease; aluminum potroom workers disease; gold-induced pneumonitis
Elevation of LDH	Alveolar proteinosis; idiopathic pulmonary fibrosis

Adapted from: Schwarz MI, King TE Jr, Cherniack RM. General principles and diagnostic approach to the interstitial lung diseases. In: Murray JF, Nadel JA (Eds), Textbook of Respiratory Medicine, 2nd ed, Philadelphia, WB Saunders Co, 1994, pp.1803-1826.

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Laboratory findings in the interstitial lung diseases