Demographics and presenting clinical features of 186 patients with fibrillary glomerulonephritis or immunotactoid glomerulonephropathy

Clinical features	Fibrillary variant		Immunotactoid variant
Clinical features	Fibril diameter*	Fibril arrangement*	Fibril diameter*	Fibril arrangement*
Number of patients^¶	172	164	12	22
Male:female	1.0:1.3	1.0:1.3	1.4:1.0	2.6:1.0
Age range	10 to 81	10 to 81	12 to 68	10 to 68
Race (White:Black)	9:1 (n=70)	9:1 (n=70)	-Δ	-Δ
Hypertension	85/126 (67%)	81/118 (69%)	5/11 (45%)	11/13 (85%)
Hematuria	109/153 (71%)	103/146 (70%)	7/11 (64%)	15/20 (75%)
Proteinuria	172/172 (100%)	164/164 (100%)	12/12 (100%)	22/22 (100%)
Nephrotic syndrome	94/133 (71%)	87/125 (70%)	9/11 (82%)	18/21 (86%)
Kidney function impairment	78/144 (54%)	73/136 (54%)	5/12 (42%)	10/22 (45%)

* To determine whether the fibrillary (F) and immunotactoid (IT) variants have different clinical features, patients were subdivided according to the diameter (F ≤30 nm) or arrangement (F, random; IT, focally organized) of microfibrils and microtubules. In general, these different criteria identified the same subpopulations of patients (>90% concordance).
¶ Fibril size was not reported in 2 patients. Study population consists of 25 patients presenting to the Brigham & Women's Hospital and 161 patients reported previously in the literature.
Δ Insufficient data for interpretation.

Adapted from Brady, HR. Kidney Int 1998; 53:1421.

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خرید پکیج

Demographics and presenting clinical features of 186 patients with fibrillary glomerulonephritis or immunotactoid glomerulonephropathy