Systemic disease | Axonal | Demyelinating | Additional comments |
Common | |||
Diabetes mellitus | Usually | Sometimes | Can be primary sensory, mixed sensorimotor, or, rarely, pure motor; autonomic involvement often present. Can be acute, subacute, or chronic. |
Critical illness | Usually | Rare if ever | Sensorimotor in most cases; can have superimposed myopathy that may add to motor phenotype. |
Carcinoma | Usually | Sometimes | Generally sensory greater than motor; autonomic involvement common as well; generally relatively rapidly progressive; sensory neuronopathy can occur. Can occur subacutely or chronically. |
Less common | |||
Uremia | Usually | Rare if ever | Sensorimotor with autonomic component. |
Connective tissue disease | Usually | Rare if ever | Sensorimotor; chronic. |
Hypoglycemia/acute correction of hyperglycemia | Sometimes | Rare if ever | Primary sensory; autonomic component may be present; can occur acutely or subacutely. |
Vitamin deficiency (excluding B12) | Usually | Rare if ever | Sensorimotor; autonomic symptoms variably present. |
Vitamin B12 deficiency | Usually | Rare if ever | Sensory; generally subacute to chronic. |
Chronic liver disease | Rare if ever | Usually | Generally sensory or sensorimotor; chronic. |
Malabsorption (sprue, celiac disease) | Sometimes | Rare if ever | Sensory or sensorimotor with possible autonomic involvement; chronic. |
HIV infection | Usually | Rare if ever | Primarily sensory; chronic. |
Lyme disease | Sometimes | Rare if ever | Sensorimotor often with substantial radicular component; subacute to chronic. |
Lymphoma, including Hodgkin | Sometimes | Sometimes | Sensory or sensorimotor; subacute or chronic. |
Multiple myeloma, osteosclerotic or solitary plasmacytoma type* | Sometimes | Usually | Sensorimotor; can present subacute or more chronically. |
IgA | Usually | Rare if ever | Sensorimotor; chronic. |
IgG | Usually | Rare if ever | Sensorimotor; chronic. |
IgM | Rare if ever | Usually | Sensorimotor or pure sensory (as in the case of anti-myelin associated glycoprotein neuropathy); subacute or chronic. |
Rare | |||
Porphyria (four types) | Usually | Rare if ever | Primarily motor; limited sensory involvement; intermittent and acute or chronic. |
Primary biliary cholangitis | Usually | Rare if ever | Primarily sensory; subacute to chronic. |
Primary systemic amyloidosis | Usually | Rare if ever | Sensorimotor with prominent autonomic involvement. |
Hypothyroidism | Usually | Rare if ever | Sensory; subacute. |
Chronic obstructive lung disease | Usually | Rare if ever | Sensory or sensorimotor; chronic. |
Acromegaly | Usually | Rare if ever | Sensory; chronic. |
Polycythemia vera | Usually | Rare if ever | Sensory; chronic. |
Cryoglobulinemia | Usually | Rare if ever | Sensorimotor; subacute. |
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