Version May 2024
| Drug | Renal toxicity (type) | Mechanism | Prevention |
| Bevacizumab and orally active tyrosine kinase inhibitors targeting VEGF (axitinib, pazopanib, sorafenib, sunitinib) | Proteinuria, nephrotic syndrome | Renal thrombotic microangiopathy? | |
| Carboplatin | Rare Hypomagnesemia; recurrent salt wasting | Tubular injury (reversible) | |
| Cetuximab | Hypomagnesemia | Tubular injury | |
| Cisplatin | Renal failure; renal tubular acidosis; hypomagnesemia (dose related and cumulative) | Tubulointerstitial injury | Aggressive hydration Forced diuresis Cytoprotectants (eg, amifostine) |
| Cyclophosphamide | Hyponatremia Hemorrhagic cystitis | Direct effect on distal tubules | Use of mesna Adequate hydration |
| Gemcitabine | Hemolytic uremic syndrome | Microangiopathic lesions | |
| Ifosfamide | Fanconi syndrome, renal tubular acidosis, nephrogenic diabetes insipidus; hemorrhagic cystitis | Proximal tubular damage by acrolein and chloroacetic acid | Use of mesna Adequate hydration Electrolyte monitoring |
| Interferons | Proteinuria; renal failure | Minimal changes; ATN | |
| Interleukin-2 | Prerenal azotemia | Renal hypoperfusion (capillary leak syndrome) | Strict patient selection Control volume and hemodynamic status Avoid other nephrotoxins |
| Methotrexate | Non-oliguric renal failure (high doses) | Intratubular deposition of methotrexate | Aggressive hydration with normal saline Urine alkalinization Forced diuresis (3 L/day) |
| Hyponatremia | SIADH | ||
| Mitomycin C | Hemolytic uremic syndrome (4 to 6%) | Microangiopathic lesions | |
| Nitrosoureas | Chronic interstitial nephritis with progressive renal failure | Glomerular sclerosis tubular fibrosis | Adequate hydration |
| Panitumumab | Hypomagnesemia | Tubular injury | |
| Rituximab | Acute renal failure | Tumor lysis syndrome | |
| Sorafenib | Proteinuria, nephrotic syndrome | Renal thrombotic microangiopathy? | |
| Streptozocin | Proteinuria common (65 to 75%); tubular syndromes | Proximal tubular damage | |
| Sunitinib | Proteinuria, nephrotic syndrome | Renal thrombotic microangiopathy? | |
| Vinca alkaloids | Hyponatremia | SIADH |
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