Immunoglobulin (Ig) genes and protein expression during B cell development

	Antigen-independent phase					Antigen-dependent phase
	Pre-pro B cell	Pro-B cell	Pre B cell	Immature B cell	Mature B cell	Activated B cell	Blast B cell	Memory B cell	Plasma B cell
Surrogate light chain		S	S + IgM H chain
Ig genes	GL	DJH	VDJH	VJL RE		CS SM RE	CS SM RE
IgM			C, H chain only	S	S	S if no CS	S if no CS	S if no CS	S if no CS
IgD					S

Note that the nomenclature of development stages varies among authors. A mature B cell may give rise to both memory cells and to plasma cells, but a single cell cannot be both. Memory cells may be activated, and subsequently divide and give rise either to new memory cells or plasma cells.
S: surface expression; GL: germline; D: diversity; J: joining; H: lg heavy chain; V: variable; RE: receptor editing; CS: class-switching; SM: somatic mutation; C: cytoplasmic expression.

Data from: Bona, CA, Bonilla, FA, Textbook of Immunology, 2nd edition, Harwood Academic Publishers, Amsterdam, 1996. page 102 (no table number).

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Immunoglobulin (Ig) genes and protein expression during B cell development