Natural history of chronic aortic regurgitation mostly based upon data from nine series with a total of 593 patients followed for a mean of 6.6 years

Asymptomatic patients with normal left ventricular (LV) systolic function
Progression to symptoms and/or LV dysfunction	Less than 6 percent/year
Progression to symptoms, LV dysfunction, or death
According to LV end-systolic dimension
>50 mm	19 percent/year
40 to 50 mm	6 percent/year
<40 mm	0 percent/year
Progression to asymptomatic LV dysfunction	Less than 3.5 percent/year
Sudden death	Less than 0.2 percent/year
Asymptomatic patients with LV systolic dysfunction
Progression to cardiac symptoms	More than 25 percent/year
Symptomatic patients
Mortality rate	More than 10 percent/year

Data from Bonow RO, Lakatos E, Maron BJ, et al. Serial long-term assessment of the natural history of asymptomatic patients with chronic aortic regurgitation and normal left ventricular systolic function. Circulation 1991; 84:1625.

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Natural history of chronic aortic regurgitation mostly based upon data from nine series with a total of 593 patients followed for a mean of 6.6 years