Mammographically occult breast cancer

A dense breast can obscure a cancer. CC and MLO views (panels A and B) in a woman with a palpable breast lump show dense breast parenchyma. No discrete mass or calcifications are seen. A sagittal post contrast MR image (panel C) in the same breast shows multiple enhancing masses (arrows) involving the upper half of the breast worrisome for malignancy. Ultrasound-guided biopsy revealed invasive ductal cancer. If there is a clinical suspicion for cancer, a negative mammogram should not stop further intervention.