Fredrickson classification of lipid disorders

Frederickson phenotype	Lipoprotein abnormality	Typical lipid levels
I	Chylomicrons	TG >99^th percentile
IIa	LDL	TC >90^th percentile; depending upon type, may also see apolipoprotein B ≥90^th percentile
IIb	LDL and VLDL	Depending upon type, TC and/or TG ≥90^th percentile and apolipoprotein B ≥90^th percentile
III	Remnants of VLDL and chylomicrons	TC and TG >90^th percentile
IV	VLDL	TC >90^th percentile; depending upon type, may also see TG >90^th percentile or low HDL
V	Chylomicrons and VLDL	TG >99^th percentile

TG: triglycerides; TC: total cholesterol; LDL: low-density lipoprotein; VLDL: very low-density lipoprotein; HDL: high-density lipoprotein.

Adapted from: Fredrickson DS. An international classification of hyperlipidemias and hyperlipoproteinemias. Ann Intern Med 1971; 75:471.

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