Hyperoxia test results in neonates with cyanosis

	PaO₂ (percent saturation) when FiO₂ = 0.21		PaO₂ (percent saturation) when FiO₂ = 1	PaCO₂
Normal	>70 (>95)		>300 (100)	35
Pulmonary disease	50 (85)		>150 (100)	50
Neurologic disease	50 (85)		>150 (100)	50
Methemoglobinemia	>70 (<85)		>200 (<85)	35
Cardiac disease
Parallel circulation*	<40 (<75)		<50 (<85)	35
Mixing with reduced PBF^¶	<40 (<75)		<50 (<85)	35
Mixing without restricted PBF^Δ	40 to 60 (75 to 93)		<150 (<100)	35
	Preductal	Postductal
Differential cyanosis^◊	70 (95)	<40 (<75)	Variable	35 to 50
Reverse differential cyanosis^§	<40 (<75)	>50 (>90)

Hyperoxia test: The typical results of PaO₂ and percent of oxygen saturation following administration of room air (FiO₂ = 0.21) or 100% oxygen (FiO₂ = 1) to neonates with different causes of cyanosis.

PaO₂: partial pressure of oxygen; FiO₂: fraction of inspired oxygen; PaCO₂: partial pressure of arterial carbon dioxide; PBF: pulmonary blood flow.
* D-transposition of the great arteries with or without ventricular septal defect.
¶ Tricuspid atresia with pulmonary stenosis or pulmonary atresia, pulmonary atresia or critical pulmonary stenosis with intact ventricular septum, tetralogy of Fallot.
Δ Truncus arteriosus, total anomalous pulmonary venous connection without obstruction, hypoplastic left heart syndrome, single ventricle without pulmonary stenosis or pulmonary atresia.
◊ Persistent pulmonary hypertension of the newborn, interrupted aortic arch, severe coarctation.
§ D-transposition of the great arteries associated with either coarctation or suprasystemic pulmonary vascular resistance.

Graphic 54070 Version 14.0

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Hyperoxia test results in neonates with cyanosis