Time course of glucocorticoid side effects

Survival curves demonstrating the time to development of the first serious adverse event (ie, the probability of remaining free of an adverse event) in patients with rheumatoid arthritis treated with no or different doses of prednisone. There is a clear dose-dependence of side effects: odds ratio 4.5 for 5 to 10 mg/day and 32.3 for 10 to 15 mg/day.