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خرید پکیج
تعداد آیتم قابل مشاهده باقیمانده : 3 مورد
نسخه الکترونیک
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Major pattern recognition receptors (PRRs) in humans: Secreted and circulating*

Major pattern recognition receptors (PRRs) in humans: Secreted and circulating*
PRR Recognize Functions
Antimicrobial peptides
Defensins Microbial membranes

Microbial cell lysis

Opsonization

Chemoattraction

Link to adaptive immunity
Cathelicidin (LL-37)
Collectins
Clq

Microbe-fixed antibody

Microbial and DAMPs membranes

Complement activation, opsonization, efferocytosis, embryonic tissue development
MBL Microbial mannan Complement activation, microbial lysis, and opsonization
Surfactant proteins A and D Microbial membranes Opsonization, lysis of bacteria and fungi, efferocytosis
Lectins
MBL Microbial carbohydrates Activation of lectin pathway of complement with microbial lysis and opsonization
Ficolins 1, 2, 3
Galectins
Pentraxins
C-reactive protein (CRP) Bacterial carbohydrate Activation of classical pathway of complement with microbial lysis and opsonization
Pentraxin 3 (PTX3)
PRR: pattern recognition receptor; Clq: first component of the C1 complex; DAMPs: damage-associated molecular patterns; MBL: mannose-binding lectin.
* This table includes major examples but is not exhaustive.
¶ Efferocytosis (Latin for "to take to the grave, to bury") refers to the process by which apoptotic cells are removed by phagocytosis.
Original figure modified for this publication. Reproduced from: Liu AH, Zasloff MA, Johnston RB Jr. Innate immunity. In: Middleton's Allergy: Principles and Practice, 7th ed, Adkinson NF Jr, Busse WW, Bochner BS, et al (Eds), Elsevier 2008. Illustration used with the permission of Elsevier, Inc. All rights reserved.
Graphic 53389 Version 10.0

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